Janice L Hyatt Selected Research

Carboxylesterase (Hydrolase S)

1/2008	Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.
12/2005	Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice.
8/2005	Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan.
8/2004	Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
6/2004	Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Janice L Hyatt Research Topics

Disease

4	Neoplasms (Cancer) 01/2008 - 12/2005
3	Diarrhea 06/2009 - 06/2004
3	Colonic Neoplasms (Colon Cancer) 12/2005 - 06/2005
2	Alzheimer Disease (Alzheimer's Disease) 03/2013 - 04/2003
2	Breast Neoplasms (Breast Cancer) 01/2008 - 09/2005
2	Glioma (Gliomas) 08/2005 - 08/2004
1	Hypertension (High Blood Pressure) 01/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2013
1	Ischemic Stroke 01/2013
1	Glioblastoma (Glioblastoma Multiforme) 01/2008
1	Brain Neoplasms (Brain Tumor) 08/2005
1	Narcotic-Related Disorders 04/2003

Drug/Important Bio-Agent (IBA)

7	Irinotecan (Camptosar)FDA LinkGeneric 09/2006 - 06/2004
6	ProdrugsIBA 06/2009 - 06/2005
5	Carboxylesterase (Hydrolase S)IBA 01/2008 - 06/2004
4	Pharmaceutical PreparationsIBA 09/2005 - 04/2003
3	CamptothecinIBA 12/2005 - 06/2004
2	CholesterolIBA 09/2005 - 04/2003
1	CarbamatesIBA 03/2013
1	Formaldehyde (Formol)FDA Link 01/2008
1	Tuberculin (PPD)IBA 01/2008
1	doxazolidineIBA 01/2008
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2008
1	Carboxylic Ester HydrolasesIBA 09/2006
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 12/2005
1	Atropine FDA LinkGeneric 12/2005
1	PoisonsIBA 12/2005
1	Cholinergic Agents (Cholinergics)IBA 12/2005
1	EsterasesIBA 12/2005
1	Tamoxifen FDA LinkGeneric 09/2005
1	benzilIBA 09/2005
1	EstersIBA 09/2005
1	ethyl acetateIBA 09/2005
1	mevastatin (CS 500)IBA 09/2005
1	Cytochrome P-450 CYP2B1 (PROD)IBA 08/2005
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 08/2005
1	EnzymesIBA 08/2004
1	Proteins (Proteins, Gene)FDA Link 08/2004
1	Antineoplastic Agents (Antineoplastics)IBA 06/2004
1	Biological ProductsIBA 06/2004
1	Tacrine (Cognex)FDA Link 04/2003
1	AcetylcholinesteraseIBA 04/2003

Therapy/Procedure

1	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2013
1	Drug Therapy (Chemotherapy) 08/2005
1	Therapeutics 08/2005